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A girl has died from what her household believes was a deadly facet impact of the weight-loss drug Ozempic.
Trish Webster, 56, from Australia, was not diabetic however was prescribed the drug off-label to assist her drop pounds forward of her daughter’s marriage ceremony.
She misplaced 35lbs (16kg) on Ozempic after which Saxenda over 5 months — whereas affected by fixed nausea, vomiting and diarrhea.
In January this yr, nonetheless, the mom collapsed at residence with a ‘brown substance’ foaming from her mouth. Her husband Roy did CPR and rolled her onto her facet to assist her breathe and save her, however she was pronounced lifeless that night.
Docs recorded her reason behind demise as ‘acute gastrointestinal sickness,’ noting Ozempic has been recognized to trigger deadly gut blockages.
Mr Webster has referred to as for a full inquiry into his spouse’s demise, saying he believes Ozempic could have been the trigger.
Trish Webster, 56, pictured above with husband Roy, died after utilizing Ozempic to lose some weight earlier than her daughter’s marriage ceremony. The mom, from Australia, suffered unwanted effects from the drug
She dropped 35lbs (16kg) over 5 months as she was making an attempt to slim down for a gown for her daughter’s marriage ceremony
Talking to Australia’s 60 Minutes Australia, he mentioned: ‘She went again a few instances to the physician saying she was sick and she or he had diarrhea and nausea.
‘[But she didn’t stop taking it because] my daughter was getting married and she or he simply saved mentioning that gown that she needed to put on.
‘She went to the dressmaker to get the measurements. It was one large nightmare from there.’
He added: ‘I by no means thought you might die from [Ozempic]. It is simply terrible. I did not know that might occur to an individual.
‘She should not be gone, you already know? It is simply not value it, it is not value it in any respect.’
Mrs Webster had beforehand tried going to the gymnasium and weight-reduction plan to shed some weight, however each had been un-successful.
She was on Ozempic for 3 months however then switched to Saxenda — additionally made by Novo Nordisk — when she could not get the drug due to main shortages.
Greater than 9 million prescriptions for Ozempic had been written within the US alone during the last three months of 2022, because the drug continues to surge in recognition.
Many of those sufferers don’t have diabetes however are as an alternative being prescribed the drug off-label due to its skill to suppress starvation and spark weight reduction.
It’s uncommon for deaths to be recorded amongst sufferers taking Ozempic.
Information from the Meals and Drug Administration (FDA) confirmed 51 fatalities have been reported amongst individuals taking the drug, though it isn’t clear for what number of of those the drug could have been concerned of their demise.
There have additionally been 18 deaths amongst individuals taking Saxenda out of the about 4 million prescriptions written yearly.
Two fatalities recorded in Ozempic sufferers beforehand led the company so as to add the side-effect ‘ileus’ to the warning label for the drug.
In Australia, there are main shortages of Ozempic pushing sufferers to make use of different medication resembling Saxenda. Information exhibits there have been three deaths reported amongst individuals on Ozempic and one amongst these on Saxenda within the nation.
Ozempic and Saxenda work by mimicking a hormone within the physique that tells somebody they’re full with a view to suppress starvation, prompting sufferers to eat much less and begin to drop pounds.
The medication additionally sluggish the passage of meals by the abdomen and small gut, additionally serving to somebody to really feel full for longer.
The FDA says this raises the danger of somebody struggling ileus, a medical situation the place the intestines turn into partially or utterly blocked.
Mrs Webster took a flip for the more serious when she collapsed and a brown substance began to foam at her mouth. Her husband tried CPR and rolling her onto her facet, however she was pronounced lifeless later that night
Mrs Webster, pictured above, ought to nonetheless be alive, her husband mentioned. He needs an investigation into her reason behind demise
Sufferers with the situation are at a better threat of bowel perforation — or a break within the intestines — or sepsis — the place the immune system goes haywire and assaults the physique’s cells — which could be deadly.
Warning indicators of ileus embody main belly ache and bloating, vomiting, extreme constipation and cramps.
Dr Michael Camilleri, a gastroenterologist on the Mayo Clinic in Minnesota, instructed DailyMail.com Mrs Webster’s case was a ‘cautionary story’ for sufferers on Ozempic and its sister medication.
He mentioned: ‘Deaths on Ozempic are extraordinarily uncommon.
‘But when sufferers on these lessons of medicines develop power gastrointestinal signs resembling nausea, postprandial fullness [or feeling excessively full] or vomiting, they might be experiencing delayed gastric emptying they usually might be liable to pulmonary aspiration [when food or substances from the stomach are inhaled into the lungs].
‘If that’s the case, somebody on Ozempic or comparable medicines ought to cease taking the drug and seek the advice of a gastroenterologist.
‘They need to additionally endure gastric emptying to see if their abdomen is emptying extra slowly.’
Dr Caroline Apovian, a weight administration professional at Brigham and Ladies’s Hospital in Boston, instructed DailyMail.com: ‘Whereas we won’t speculate on this specific case, issues are doable for anybody taking these medicines.
‘[Patients] must be fastidiously overseen by an endocrinologist or different certified medical skilled who can tackle issues once they come up.’
Ozempic makes use of semaglutide to suppress urge for food and sluggish the digestive system, making individuals really feel full even after a really small meal.
Saxenda works in an analogous approach however makes use of a distinct drug referred to as liraglutide.
A spokesperson for Novo Nordisk say the complication of ileus was solely noticed after ‘post-marketing authorization’, or when the drug was rolled out to cabinets.
A spokesman for the FDA mentioned they proceed to observe for potential side-effects from Ozempic.
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