Felodipine is a medicine used to treat high blood pressure.

If you have high blood pressure, taking felodipine helps to prevent future heart disease, heart attacks and strokes.

Felodipine is also used to prevent angina (chest pain caused by heart disease).

This medicine is only available on prescription. It comes as tablets.

  • Felodipine lowers your blood pressure and makes it easier for your heart to pump blood around your body.
  • It’s usual to take felodipine once a day in the morning.
  • If you get severe vomiting or diarrhoea from a stomach bug or illness, tell your doctor. You may need to stop taking felodipine for a while until you feel better.
  • Do not eat grapefruit or drink grapefruit juice while you’re taking felodipine. Grapefruit can make side effects worse.
  • Felodipine is also called by various brand names, including Plendil, Cardioplen XL, Folpik XL, Vascalpha and Neofel XL.

Adults aged 18 and over can take felodipine.

Felodipine isn’t suitable for some people.

To make sure felodipine is safe for you, tell your doctor if you:

  • have had an allergic reaction to felodipine or any other medicine in the past
  • are trying to get pregnant, are already pregnant or if you are breastfeeding
  • have heart failure or heart disease or you’ve recently had a heart attack
  • have new chest pain or chest pain that lasts longer or is more severe than usual
  • have liver problems

Take felodipine as your doctor has told you, and follow the
directions on the label. If you’re not sure, check with your doctor or
pharmacist.

Felodipine comes as ‘prolonged release’ tablets (sometimes
called ‘modified release’). This means that the tablets release
felodipine slowly and evenly throughout the day.

How much will I take?

Your dose of felodipine depends on why you need the medicine. To
decide the correct dose for you, your doctor will check your blood
pressure.

The usual starting dose of felodipine for high blood pressure and angina is 5mg once a day.

Elderly patients usually start on a lower dose of 2.5mg once a day.

How to take it

It’s usual to take felodipine once a day in the morning. It’s best to
take it on an empty stomach or after a light meal or snack that isn’t
too fatty or starchy.

Swallow the tablets whole with a glass of water. Do not break, crush
or chew them. Talk to your pharmacist or doctor if you have problems
swallowing them.

Do not eat or drink grapefruit or grapefruit juice while you’re
taking this medicine. Grapefruit juice can make side effects worse.

Will my dose go up or down?

If the starting dose isn’t working well enough, your doctor may increase it to 10mg a day.

If you have side effects or your blood pressure goes too low, your doctor may lower your dose to 2.5mg a day.

Like all medicines, felodipine can cause side effects, although not everyone gets them. Side effects often improve as your body gets used to the medicine.

Common side effects

These common side effects happen in more than 1 in 100 people. They are usually mild and short-lived.

Talk to your doctor or pharmacist if the side effects bother you or last for more than a few days:

  • headaches
  • dizziness
  • flushing (feeling hot)
  • a pounding heartbeat
  • swollen ankles

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people.
Stop taking the medicine and contact a doctor straight away if you get:

  • chest pain that is new or worse – this side effect needs to be checked out as chest pain is a possible symptom of a heart attack

Serious allergic reaction

In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to felodipine.

What to do about:

  • headaches – make sure you rest and drink plenty of
    fluids. Don’t drink too much alcohol. Ask your pharmacist to recommend a
    painkiller. Headaches should usually go away after the first week of
    taking felodipine. Talk to your doctor if they last longer than a
    week or are severe.
  • feeling dizzy – if felodipine makes you feel dizzy, stop what you’re doing and sit or lie down until you feel better
  • flushing – try cutting down on coffee, tea
    and alcohol. It might help to keep the room cool and use a fan. You
    could also spray your face with cool water or sip cold or iced drinks.
    The flushing should go away after a few days. If it doesn’t go away, or
    if it’s causing you problems, contact your doctor.
  • swollen ankles – raise your legs while you’re sitting down

Felodipine is not recommended in pregnancy or when breastfeeding.

If you’re trying to get pregnant or you’re already pregnant, talk to your doctor about the benefits and possible harms of taking felodipine. There are usually other medicines that are safer for you.

Felodipine and breastfeeding

Small amounts of felodipine may get into breast milk, but it’s not
known if this is harmful to the baby. Talk to your doctor as other
medicines might be better while you’re breastfeeding.

If you take other medicines that lower blood pressure with
felodipine, the combination can sometimes lower your blood pressure too
much. This may make you feel dizzy or faint. If this keeps happening to
you, tell your doctor as your dose may need to be changed.

Some medicines can interfere with the way felodipine works.

Tell your doctor if you’re taking any of these medicines before starting felodipine:

  • anti-epilepsy medicines: carbamazepine, phenytoin, phenobarbital (phenobarbitone) or primidone
  • antibiotics: clarithromycin, erythromycin or rifampicin
  • the antifungal itraconazole
  • medicines for HIV or HCV (hepatitis C virus)
  • medicines to reduce immune reactions such as ciclosporin or tacrolimus

Mixing felodipine with herbal remedies or supplements

To be safe, speak to your pharmacist or doctor before taking any herbal or alternative remedies with felodipine.

St John’s wort, a herbal medicine taken for depression, is thought to
interfere with the way felodipine works. Talk to your doctor if you’re
thinking about taking St John’s wort.

How does felodipine work?