Amlodipine is a medicine used to treat high blood pressure. If you have high blood pressure, taking amlodipine helps to prevent future heart disease, heart attacks and strokes.

Amlodipine is also used to prevent angina (chest pain caused by heart disease).

This medicine is only available on prescription. It comes as tablets or as a liquid to swallow.

  • Amlodipine lowers your blood pressure and makes it easier for your heart to pump blood around your body.
  • It’s usual to take amlodipine once a day.You can take it at any time of day, but try to make sure it’s around the same time each day.
  • The most common side effects include headaches, flushing, feeling tired and swollen ankles. These usually improve after a few days.
  • Amlodipine can be called amlodipine besilate, amlodipine maleate or amlodipine mesilate. This is because the medicine contains another chemical to make it easier for your body to take up and use it. It doesn’t matter what your amlodipine is called. They all work as well as each other.
  • Amlodipine is also called by the brand names Istin and Amlostin.

Amlodipine can be taken by adults and children aged 6 years and over.

Amlodipine isn’t suitable for some people.

To make sure amlodipine is safe for you, tell your doctor if you:

  • have had an allergic reaction to amlodipine or any other medicines in the past
  • are trying to get pregnant, are already pregnant or you are breastfeeding
  • have liver or kidney disease
  • have heart failure or you’ve recently had a heart attack

Take amlodipine exactly as your doctor has told you, and follow the
directions on the label. If you’re not sure, check with your doctor or
pharmacist.

It’s usual to take amlodipine once a day. You can take amlodipine at
any time of day, but try to make sure it’s around the same time every
day.

How much will I take?

Amlodopine comes as 5mg and 10mg tablets.

Your dose of amlodipine depends on why you need the medicine.

To decide the correct dose for you, your doctor will check your blood pressure and ask if you’re getting any side effects.

Depending on why you’re taking amlodipine, the usual starting dose is 5mg once a day.

If the starting dose isn’t working well enough (your blood pressure does not lower enough, or your angina isn’t controlled), you may need to increase your dose to 10mg.

Doses may be lower for children.

How to take it

You can take amlodipine with or without food.

Swallow amlodipine tablets whole with a drink of water. If it’s easier, you can dissolve the tablets in a glass of water, but if you do this you must drink the solution straight away.

Don’t eat or drink lots of grapefruit or grapefruit juice while you’re taking this medicine. Grapefruit can increase the concentration of amlodipine in your body and worsen side effects.

If you’re taking amlodipine as a liquid, it will come with a plastic syringe or spoon to help you measure out the right dose. If you don’t have one, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give the right amount of medicine. Do not mix the liquid with food or other drinks before taking it.

Like all medicines, amlodipine can cause side effects although not everyone gets them. Side effects often improve as your body gets used to the medicine.

Common side effects

These common side effects happen in more than 1 in 100 people. They are usually mild and short-lived.

Talk to your doctor or pharmacist if the side effects bother you or last for more than a few days:

Serious side effects

Serious side effects after taking amlodipine are rare and happen in less than 1 in 10,000 people.

Tell a doctor straight away if you get:

  • stomach problems – severe pain in your tummy, with or without bloody diarrhoea, feeling sick and being sick can be signs of pancreatitis
  • yellow skin or eyes – this can be a sign of liver problems
  • chest pain that is new or worse – this needs to be checked out as chest pain is a possible symptom of a heart attack

Serious allergic reaction

In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to amlodipine.

What to do about:

  • headaches – make sure you rest and drink plenty of fluids. Don’t drink too much alcohol. Ask your pharmacist to recommend a painkiller. Headaches should usually go away after the first week of taking amlodipine. Talk to your doctor if they last longer than a week or are severe.
  • feeling dizzy – if amlodipine makes you feel dizzy, stop what you’re doing and sit or lie down until you feel better
  • flushing – try cutting down on coffee, tea and alcohol. It might help to keep the room cool and use a fan. You could also spray your face with cool water or sip cold or iced drinks. The flushing should go away after a few days. If it doesn’t go away, or if it’s causing you problems, contact your doctor.
  • swollen ankles – raise your legs while you’re sitting down

Amlodipine is not normally recommended in pregnancy or when breastfeeding.

If you’re trying to get pregnant or you’re already pregnant, talk to your doctor about the benefits and possible harms of taking amlodipine. There may be other medicines that are safer for you.

Amlodipine and breastfeeding

Small amounts of amlodipine may get into breast milk, but it’s not known if this is harmful to the baby. Talk to your doctor as other medicines might be better while you’re breastfeeding.

If you take other medicines that lower blood pressure, such as ramipril and lisinopril, at the same time as amlodipine, the combination can sometimes lower your blood pressure too much. This may make you feel dizzy or faint. If this keeps happening to you, tell your doctor as your dose may need to be changed.

Some medicines can interfere with the way amlodipine works.

Tell your doctor if you’re taking any of these medicines before starting amlodipine:

  • the antibiotics clarithromycin, erythromycin or rifampicin
  • medicines for high blood pressure including diltiazem and verapamil
  • the antifungals itraconazole or ketoconazole
  • medicines to treat HIV or HCV (hepatitis C virus)
  • the anti-epilepsy medicines, carbamazepine, phenytoin, phenobarbital (phenobarbitone) or primidone
  • medicines to suppress your immune system such as ciclosporin or tacrolimus
  • more than 20mg a day of the cholesterol-lowering medicine, simvastatin

Mixing amlodipine with herbal remedies or supplements

St John’s wort, a herbal medicine taken for depression, is thought to interfere with the way amlodipine works. Talk to your doctor if you’re thinking about taking St John’s wort.

How does amlodipine work?